Markus Schosserer

Additionally: ORCID.

(1) Schosserer M, Minois N, Angerer TB, Amring M, Dellago H, Harreither E, Calle-Perez A, Pircher A, Gerstl MP, Pfeifenberger S, Brandl C, Mohr T, Sonntagbauer M, Kriegner A, Linder A, Weinhäusel A, Steiger M, Mattanovich D, Rinnerthaler M, Karl T, Sharma S, Entian KD, Kos M, Breitenbach M, Wilson IBH, Polacek N, Grillari-Voglauer R, Breitenbach-Koller L, Grillari J. Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan. Nat Commun 2015;6:6158. doi:10.1038/ncomms7158.

This paper establishes for the first time a causal and evolutionarily well-conserved connection between RNA methylation and lifespan regulation in yeast, nematodes, and fruit flies. This work on NSUN5 initiated our research on RNA methylation in the context of aging and physiology. More than 140 articles cited this work.

(2) Heissenberger C, Rollins JA, Krammer TL, Nagelreiter F, Stocker I, Wacheul L, Shpylovyi A, Tav K, Snow S, Grillari J, Rogers AN, Lafontaine DLJ, Schosserer M*. The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans. eLife 2020; 9:e56205. doi: 10.7554/eLife.56205 (*corresponding author).

This paper further expands our previous work on RNA methylations‘ physiological roles. It demonstrates that the two m5C RNA-methyltransferases NSUN-1 and NSUN-5 distinctly modulate essential processes such as aging and development in nematodes.

(3) Heissenberger C, Liendl L, Nagelreiter F, Gonskikh Y, Yang G, Stelzer EM, Krammer TL, Micutkova L, Vogt S, Kreil DP, Sekot G, Siena E, Poser I, Harreither E, Linder A, Ehret V, Helbich TH, Grillari-Voglauer R, Jansen-Dürr P, Koš M, Polacek N, Grillari J, Schosserer M*. Loss of the ribosomal RNA methyltransferase NSUN5 impairs global protein synthesis and normal growth. Nucleic Acids Res 2019;47(22):11807-11825. doi: 10.1093/nar/gkz1043 (*corresponding author).

In this paper, we characterize the molecular function of the rRNA methyltransferase NSUN5 in mammalian cells and demonstrate the physiological consequences of methylation loss in mice.

(4) Nagelreiter F, Coats MT, Klanert G, Gludovacz E, Borth N, Grillari J, Schosserer M*. OPP labeling enables total protein synthesis quantification in CHO production cell lines at the single-cell level. Biotechnol J 2018;13(4):e1700492. doi: 10.1002/biot.201700492.

This paper describes a novel protocol to quantify global protein synthesis by flow cytometry at the single-cell level in biotechnologically relevant CHO cells.

(5) Schosserer M, Banks G, Dogan S, Dungel P, Fernandes A, Presen DM, Matheu A, Osuchowski M, Potter P, Sanfeliu C, Tuna BG, Varela- Nieto I, Bellantuono I. Modelling physical resilience in ageing mice. Mech Ageing Dev 2019;177:91- 102. doi: 10.1016/j.mad.2018.10.001.

This review paper introduced physical resilience as a novel readout for aging interventional studies in mice and was developed together with leading experts in the field within the “MouseAGE“ COST Action.

(6) Garschall K, Dellago H, Gáliková M, Schosserer M*, Flatt T*, Grillari J. Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span. NPJ Aging Mech of Dis 2017; 3(5). doi: 10.1038/s41514-017-0005-z (*shared corresponding authors).

This paper is one of the first reports that ectopic overexpression of a DNA repair factor can prolong an organism‘s lifespan. It thereby represents an extension of our previous cell culture studies on PRP19/SNEV.

(7) Khan A, Dellago H, Terlecki-Zaniewicz L, Karbiener M, Weilner S, Hildner F, Steininger V, Gabriel C, Mück C, JansenDürr P, Hacobian A, Scheideler M, Grillari-Voglauer R, Schosserer M*, Grillari J*. SNEV(hPrp19/hPso4) regulates adipogenesis of human adipose stromal cells. Stem Cell Reports 2017; 8(1):21-29. doi: 10.1016/j.stemcr.2016.12.001 (*shared corresponding authors).

This paper establishes a novel causal link between DNA damage repair and adipogenic differentiation in ASCs and C. elegans. It thereby expands our previous studies on PRP19/SNEV in endothelial cells.

(8) Schosserer M*, Grillari J, Breitenbach M. The dual role of cellular senescence in developing tumors and their response to cancer therapy. Front Oncol 2017;7:278. doi: 10.3389/fonc.2017.00278 (*corresponding author).

This review paper describes the complex interaction between senescence and cancer and suggests potential therapeutic approaches. More than 120 articles cited this work.

(9) Schosserer M, Grillari J, Wolfrum C, Scheideler M. Age-induced changes in white, brite, and brown adipose depots: A Mini-Review. Gerontology 2018;64(3):229-236. doi: 10.1159/000485183.

This review paper summarizes functional changes occurring in different adipose depots during aging and senescence.

(10) Liendl L, Grillari J, Schosserer M*. Raman fingerprints as promising markers of cellular senescence and aging. Geroscience 2020;42(2):377-387. doi: 10.1007/s11357-019-00053-7 (*corresponding author).

This review paper introduces Raman microspectroscopy as a novel tool to identify senescent cells and characterize aging-associated phenomena.