Pidder Jansen-Dürr

Additionally: ORCID.

(1) Wedel S, Martic I, Guerrero Navarro L, Ploner C, Pierer G, Jansen-Dürr P, Cavinato M. Depletion of growth differentiation factor 15 (GDF15) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts. Aging Cell. 2023 Jan;22(1):e13752. doi: 10.1111/acel.13752.

In this paper, we describe for the first time that the mitokine GDF15 plays an important role for mitochondrial quality control in skin aging.

(2) Martic I, Wedel S, Jansen-Dürr P, Cavinato M. A new model to investigate UVB-induced cellular senescence and pigmentation in melanocytes. Mech Ageing Dev. 2020 Sep;190:111322. doi: 10.1016/j.mad.2020.111322.

In this paper, we establish the first in-vitro model for UV-induced senescence and pigmentation in human skin melanocytes.

(3) Weiss AKH, Naschberger A, Loeffler JR, Gstach H, Bowler MW, Holzknecht M, Cappuccio E, Pittl A, Etemad S, Dunzendorfer-Matt T, Scheffzek K, Liedl KR, Jansen-Dürr P. Structural basis for the bi- functionality of human oxaloacetate decarboxylase FAHD1. Biochem J 2018;475(22):3561-3576. doi: 10.1042/BCJ20180750.

This paper establishes the structure of the catalytic center of FAHD1 and provides a mechanism for its dual catalytic function.

(4) Cavinato M, Koziel R, Romani N, Weinmüllner R, Jenewein B, Hermann M, Dubrac S, Ratzinger G, Grillari J, Schmuth M, Jansen-Dürr P. UVB-induced senescence of human dermal fibroblasts involves impairment of proteasome and enhanced autophagic activity. J Gerontol A Biol Sci Med Sci 2017;72(5):632-639. doi:10.1093/gerona/glw150.

In this paper, we show for the first time that autophagy is required to establish senescence in human cells.

(5) Pircher H, von Grafenstein S, Diener T, Metzger C, Albertini E, Taferner A, Unterluggauer H, Kramer C, Liedl KR, Jansen-Dürr P. Identification of FAH domain containing protein 1 (FAHD1) as oxaloacetate decarboxylase. J Biol Chem 2015;290(11):6755-6762. doi:10.1074/jbc.M114.609305.

In this paper, we identify FAHD1 as the first eukaryotic oxaloacetate decarboxylase.

(6) Koziel R, Ruckenstuhl C, Albertini E, Neuhaus M, Netzberger C, Bust M, Madeo F, Wiesner RJ, Jansen- Dürr P. Methionine restriction slows down senescence in human diploid fibroblasts. Aging Cell 2014;13(6):1038-1048. doi:10.1111/acel.12266.

In this paper, we show that methionine restriction can delay senescence in human cells by modifying mitochondrial translation.

(7) Koziel R, Greussing R, Maier AB, Declercq L, Jansen-Dürr P. Functional interplay between mitochondrial and proteasome activity in skin aging. J Invest Dermatol 2011;131(3):594-603. doi:10.1038/jid.2010.383.

This paper is the first to report the interdependence between mitochondrial and proteasome activity in human skin in vivo.

(8) Laschober GT, Ruli D, Hofer E, Mück C, Carmona-Gutierrez D, Ring J, Hütter E, Ruckenstuhl C, Micutkova L, Brunauer R, Jamnig A, Trimmel D, Herndler-Brandstetter D, Brunner S, Zenzmaier C, Sampson N, Breitenbach M, Fröhlich KU, Grubeck-Loebenstein B, Jansen-Dürr P, et al. Identification of evolutionarily conserved genetic regulators of cellular aging. Aging Cell 2010;9(6):1084-1097. doi:10.1111/j.1474-9726.2010.00637.x.

In this paper, we report the identification of novel senescence regulators based on a functional screen in yeast.

(9) Zwerschke W, Mazurek S, Massimi P, Banks L, Eigenbrodt E, Jansen-Dürr P. Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein. Proc Natl Acad Sci U S A 1999;96(4):1291-1296. doi: 10.1073/pnas.96.4.1291.

This paper reports for the first time that pyruvate kinase activity is modulated by a viral oncoprotein, anticipating the new field of tumor metabolism.

(10) Pagano M, Draetta G, Jansen-Dürr P. Association of cdk2 kinase with the transcription factor E2F during S phase. Science 1992;255(5048):1144-1147. doi: 10.1126/science.1312258.

This paper reports for the first time the association of a cyclin-dependent kinase with a transcription factor establishing a mechanism of cell cycle-regulated gene expression.